Celiac Disease: A Comprehensive Review of Epidemiology, Pathogenesis, and Therapeutic Strategies.

doi:10.1007/s10620-026-09860-3

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Article

Celiac Disease: A Comprehensive Review of Epidemiology, Pathogenesis, and Therapeutic Strategies.

Digestive diseases and sciences - 1 Sept 2026

Amakye Dominic, Clarke Kofi

Abstract excerpt

Celiac disease (CD) is a T-cell-immune mediated enteropathy triggered by gluten ingestion in genetically susceptible individuals. The estimated global prevalence is 1% (range 0.7-1.4%), and the clinical manifestation results from a complex interplay of genetic, immunologic, and environmental factors. Although it occurs predominantly in predisposed individuals with the genetic haplotypes HLA-DQ2, HLA-DQ8, or...

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PMID: 41975174
DOI: 10.1007/s10620-026-09860-3
PMCID: PMC13522035

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