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Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight.

Human molecular genetics - 4 Jun 2022

Thompson William D, Beaumont Robin N, Kuang Alan, Warrington Nicole M, Ji Yingjie, Tyrrell Jessica, Wood Andrew R, Scholtens Denise M, Knight Bridget A, Evans David M, Lowe William L, Santorelli Gillian, Azad Raq, Mason Dan, Hattersley Andrew T, Frayling Timothy M, Yaghootkar Hanieh, Borges Maria Carolina, Lawlor Deborah A, Freathy Rachel M

Abstract excerpt

BACKGROUND: Higher birthweight is associated with higher adult body mass index (BMI). Alleles that predispose to greater adult adiposity might act in fetal life to increase fetal growth and birthweight. Whether there are fetal effects of recently identified adult metabolically favorable adiposity alleles on birthweight is unknown. AIM: We aimed to test the effect on birthweight of fetal genetic predisposition to...

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Share to Adiposity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 34897462
DOI: 10.1093/hmg/ddab356
PMCID: PMC9169452

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