Article
Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother-infant pairs.
PLoS medicine - 1 Aug 2020
Chen Jing, Bacelis Jonas, Sole-Navais Pol, Srivastava Amit, Juodakis Julius, Rouse Amy, Hallman Mikko, Teramo Kari, Melbye Mads, Feenstra Bjarke, Freathy Rachel M, Smith George Davey, Lawlor Deborah A, Murray Jeffrey C, Williams Scott M, Jacobsson Bo, Muglia Louis J, Zhang Ge
Abstract excerpt
BACKGROUND: Many maternal traits are associated with a neonate's gestational duration, birth weight, and birth length. These birth outcomes are subsequently associated with late-onset health conditions. The causal mechanisms and the relative contributions of maternal and fetal genetic effects behind these observed associations are unresolved. METHODS AND FINDINGS: Based on 10,734 mother-infant duos of European...
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