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Do maternal intrauterine environmental influences that lower offspring birthweight causally increase offspring cardiometabolic risk factors in later life? A Mendelian randomization study of 45,849 genotyped parent offspring pairs in the HUNT study

2020-05-08

Abstract excerpt

<h4>Introduction</h4> There is a robust and well-documented observational relationship between lower birthweight and higher risk of cardiometabolic disease in later life. The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that adverse environmental factors in utero or in the early years of life result in increased future risk of cardiometabolic disease. Our aim was to investigate whether the...

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Literature Corpus work
c13203ae-8abf-55cd-a0b2-c1e40e7eb513
DOI
10.1101/2020.05.04.20091173
Open publication

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Do maternal intrauterine environmental influences that lower offspring birthweight causally increase offspring cardiometabolic risk factors in later life? A Mendelian randomization study of 45,849 genotyped parent offspring pairs in the HUNT studyDOI 10.1101/2020.05.04.20091173
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