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Article

Progranulin genetic variant rs5848 displays ancestry-specific associations with Alzheimer's disease.

Human genomics - 13 Apr 2026

Life Benjamin E, Navarro-Delgado Erick I, Fornes Oriol, Friedman Jan M, Wasserman Wyeth W, Korthauer Keegan, Leavitt Blair R

Abstract excerpt

BACKGROUND: Progranulin is a molecular modifier of Alzheimer’s disease (AD). However, its cis-regulatory region remains under-characterized. Association studies of genetic variants in this region with AD have obtained conflicting results across different human populations. METHODS: We define the cis-regulatory region of the progranulin gene (GRN). Querying the genetically admixed Alzheimer’s Disease Sequencing...

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Identifiers

PMID: 41975535
DOI: 10.1186/s40246-026-00958-3
PMCID: PMC13200471

Genes

GRN
MAF

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