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Article

Evidence for GRN connecting multiple neurodegenerative diseases

1 Apr 2021

Abstract excerpt

Abstract Previous research using genome-wide association studies has identified variants that may contribute to lifetime risk of multiple neurodegenerative diseases. However, whether there are common mechanisms that link neurodegenerative diseases is uncertain. Here, we focus on one gene, GRN, encoding progranulin, and the potential mechanistic interplay between genetic risk, gene expression in the brain and...

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PMID: 34693284
DOI: 10.1093/braincomms/fcab095

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