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Article

Genome-wide meta-analysis identifies ancestry-specific loci for Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2024

Ge Yi-Jun, Chen Shi-Dong, Wu Bang-Sheng, Zhang Ya-Ru, Wang Jun, He Xiao-Yu, Liu Wei-Shi, Chen Yi-Lin, Ou Ya-Nan, Shen Xue-Ning, Huang Yu-Yuan, Gan Yi-Han, Yang Liu, Ma Ling-Zhi, Ma Ya-Hui, Chen Ke-Liang, Chen Shu-Fen, Cui Mei, Tan Lan, Dong Qiang, Zhao Qian-Hua, Wang Yan-Jiang, Jia Jian-Ping, Yu Jin-Tai

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) is a devastating neurological disease with complex genetic etiology. Yet most known loci have only identified from the late-onset type AD in populations of European ancestry. METHODS: We performed a two-stage genome-wide association study (GWAS) of AD totaling 6878 Chinese and 63,926 European individuals. RESULTS: In addition to the apolipoprotein E (APOE) locus, our GWAS of...

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Identifiers

PMID: 39023044
DOI: 10.1002/alz.14121
PMCID: PMC11497642

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