Article
Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study.
The Lancet. Neurology - 1 Jun 2026
Patel Maulikkumar, Feng Wei, Mckay Nicole S, Millar Peter R, Liu Menghan, Yang Chengran, Cetin Arda, Johnson Matthew, Budde John, Western Daniel, Marsh Thomas W, Saliu Ibrahim O, Gordon Brian A, Guerra Jorge J Llibre, Morris John C, Bateman Randall J, McDade Eric, Holtzman David M, Ryan Natalie S, Benzinger Tammie L S, Renton Alan E, Goate Alison M, Ibanez Laura, Sung Yun Ju, Zhao Guoyan, Cruchaga Carlos, Pottier Cyril
Abstract excerpt
BACKGROUND: Individuals with autosomal dominant Alzheimer's disease (ADAD) arising from mutations in PSEN1, PSEN2, or APP exhibit variability in clinical presentation. Genetic studies of ADAD have shaped our understanding of the disease, and the discovery of genetic modifiers can inform therapeutic interventions and improve patient outcomes. We aimed to discover new genetic modifiers in individuals with mutations...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.