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Article

Biosensor-driven adaptive laboratory evolution of l-valine production in Corynebacterium glutamicum.

Metabolic engineering - 1 Nov 2015

Mahr Regina, Gätgens Cornelia, Gätgens Jochem, Polen Tino, Kalinowski Jörn, Frunzke Julia

Abstract excerpt

Adaptive laboratory evolution has proven a valuable strategy for metabolic engineering. Here, we established an experimental evolution approach for improving microbial metabolite production by imposing an artificial selective pressure on the fluorescent output of a biosensor using fluorescence-activated cell sorting. Cells showing the highest fluorescent output were iteratively isolated and (re-)cultivated. The...

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PMID: 26453945
DOI: 10.1016/j.ymben.2015.09.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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