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Modeling metabolic syndrome through structural equations of metabolic traits, comorbid diseases, and GWAS variants.

Obesity (Silver Spring, Md.) - 1 Dec 2013

Karns Rebekah, Succop Paul, Zhang Ge, Sun Guangyun, Indugula Subba R, Havas-Augustin Dubravka, Novokmet Natalija, Durakovic Zijad, Milanovic Sanja Music, Missoni Sasa, Vuletic Silvije, Chakraborty Ranajit, Rudan Pavao, Deka Ranjan

Abstract excerpt

OBJECTIVE: To provide a quantitative map of relationships between metabolic traits, genome-wide association studies (GWAS) variants, metabolic syndrome (MetS), and metabolic diseases through factor analysis and structural equation modeling (SEM). DESIGN AND METHODS: Cross-sectional data were collected on 1,300 individuals from an eastern Adriatic Croatian island, including 14 anthropometric and biochemical...

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PMID: 23512735
DOI: 10.1002/oby.20445

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