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Article

FcγRIIb deficiency inhibits tumor development by attenuating the immunosuppressive phenotype of MDSCs.

Immunology letters - 1 Aug 2026

Chen Wenyan, Pan JiaHua, Ning Xiaomin, Li Dongkun, Shen Tingting, Cai Liangliang, Wang Shaoqing, Qian Li, Zhu Xiaoyu

Abstract excerpt

Regulation of myeloid-derived suppressor cell (MDSC) programming is critical for controlling tumor growth and anti-tumor immune responses. The role of FcγRIIb in MDSC programming was examined. FcγRIIb deficiency was found to promote MDSC differentiation and increase splenic MDSC accumulation in tumor-bearing mice. This deficiency also attenuated the immunosuppressive phenotype of both polymorphonuclear...

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PMID: 41974282
DOI: 10.1016/j.imlet.2026.107177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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