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Article

Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer.

Nature immunology - 1 Mar 2013

Youn Je-In, Kumar Vinit, Collazo Michelle, Nefedova Yulia, Condamine Thomas, Cheng Pingyan, Villagra Alejandro, Antonia Scott, McCaffrey Judith C, Fishman Mayer, Sarnaik Amod, Horna Pedro, Sotomayor Eduardo, Gabrilovich Dmitry I

Abstract excerpt

Two major populations of myeloid-derived suppressor cells (MDSCs), monocytic MDSCs (M-MDSCs) and polymorphonuclear MDSCs (PMN-MDSCs) regulate immune responses in cancer and other pathologic conditions. Under physiologic conditions, Ly6C(hi)Ly6G(-) inflammatory monocytes, which are the normal counterpart of M-MDSCs, differentiate into macrophages and dendritic cells. PMN-MDSCs are the predominant group of MDSCs...

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Share to Dendritic Cells
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Genes, Retinoblastoma

Share to Macrophages

Share to Monocytes

Share to Myeloid Cells

Share to Retinoblastoma Protein

Source

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Identifiers

PMID: 23354483
DOI: 10.1038/ni.2526
PMCID: PMC3578019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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