Article
Integrated genomic profiling identifies predictive biomarkers for neoadjuvant therapy response in Chinese breast cancer patients.
Cancer letters - 28 Jul 2026
Ying Xiao-Han, Zhang Kun-Yu, Jiang Shu-Hao, Chen Li, Li Jun-Jie, Liu Guang-Yu, Yu Ke-Da, Wu Jiong, Di Gen-Hong, Wang Yun-Yi, Fan Lei, Hou Yi-Feng, Shao Zhi-Ming, Zhu Xiu-Zhi, Hu Xin, Chen Chao, Wang Zhong-Hua
Abstract excerpt
Neoadjuvant therapy (NAT) has emerged as a standard treatment strategy for locally advanced breast cancer (BC), yet robust biomarkers for response prediction remain elusive. Here, we established a real-world NAT cohort of 1161 Chinese BC patients, including 1145 cases with matched clinicopathological data and targeted sequencing, to systematically evaluate genomic features associated with NAT outcomes. We...
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