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Comprehensive genomic profiling and therapeutic implications for Taiwanese patients with treatment-naïve breast cancer.

Cancer medicine - 1 Jun 2024

Chen Shang-Hung, Tse Ka-Po, Lu Yen-Jung, Chen Shu-Jen, Tian Yu-Feng, Tan Kien Thiam, Li Chien-Feng

Abstract excerpt

BACKGROUND: Breast cancer is a heterogeneous disease categorized based on molecular characteristics, including hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) expression levels. The emergence of profiling technology has revealed multiple driver genomic alterations within each breast cancer subtype, serving as biomarkers to predict treatment outcomes. This study aimed to explore the...

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Identifiers

PMID: 38895905
DOI: 10.1002/cam4.7384
PMCID: PMC11187859

Genes

PIK3CA
FGFR1
AKT2
EGFR
FGFR3
GATA3
KMT2C
MAP3K1
NF1
SF3B1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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