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Article

Decoding molecular signatures and identifying therapeutic targets in triple-negative breast cancer subtypes using omics and network analysis.

Scientific reports - 24 Dec 2025

Sanyal Debapriya, AlShahrani Abdullah M, Kar Soumya, Ahmad S Rehan, Mal Chittabrata, Mondal Sunil Kanti

Abstract excerpt

Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer. It is resistant to therapeutic applications, making it very difficult to manage. Most patients continue to receive chemotherapy. The main challenges in treating TNBC arise from its histopathological, transcriptomic, and genomic heterogeneity. While subtype classification was once essential for understanding TNBC's diverse behavior,...

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Identifiers

PMID: 41444310
DOI: 10.1038/s41598-025-28191-3
PMCID: PMC12738556

Genes

AKT1
AXIN2
ERBB3
ERBB4
FGFR4
GNAS

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