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Myc promotes polyploidy in murine trophoblast cells and suppresses senescence

9 May 2023

Abstract excerpt

The placenta is essential for reproductive success. The murine placenta includes polyploid giant cells that are crucial for its function. Polyploidy occurs broadly in nature but its regulators and significance in the placenta are unknown. We have discovered that many murine placental cell types are polyploid and have identified factors that license polyploidy using single-cell RNA sequencing. Myc is a key...

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PMID: 37278344
DOI: 10.1242/dev.201581

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