Article
Persistent DNA Damage and Senescence in the Placenta Impacts Developmental Outcomes of Embryos.
Developmental cell - 10 Aug 2020
Singh Vijay Pratap, McKinney Sean, Gerton Jennifer L
Abstract excerpt
Cohesin is an evolutionarily conserved chromosome-associated protein complex essential for chromosome segregation, gene expression, and repair of DNA damage. Mutations that affect this complex cause the human developmental disorder Cornelia de Lange syndrome (CdLS), thought to arise from defective embryonic transcription. We establish a significant role for placental defects in the development of CdLS mouse...
Topics
- Animals
- Chromosome Segregation
- DNA Damage
- De Lange Syndrome
- Female
- Gene Expression
- Humans
- Mice
- Mutation
- Phenotype
- Placenta
- Pregnancy