Brain MRI iron deposition and serum iron with multiple sclerosis: Evidence from a Mendelian randomization study.

Abstract excerpt

BACKGROUND: Accumulating evidence suggests abnormal iron deposition in the brains of patients with multiple sclerosis (MS). However, the causal relevance of brain iron deposition, as well as its relationship with systemic iron status, remains uncertain. METHODS: To investigate potential causal associations, we conducted Mendelian randomization (MR) analyses using summary data from the International Multiple...

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