Mapping the conformational variability in mutants of the amyloid precursor protein intracellular domain.

Abstract excerpt

The amyloid precursor protein intracellular domain (AICD) is an intrinsically disordered regulatory segment whose conserved YENPTY motif mediates transient interactions with multiple adaptor and signaling proteins. How sequence perturbations within this motif modulate its accessibility and interaction potential within a disordered ensemble remains poorly understood. Here, we combine small-angle X-ray scattering,...

Topics

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• Amino Acid Motifs
• Amyloid beta-Protein Precursor
• Circular Dichroism
• Molecular Dynamics Simulation
• Mutation