Article

Monomer binding modes of small molecules that modulate the kinetics of hIAPP amyloid formation

2025-09-24

Abstract excerpt

Human islet amyloid polypeptide (hIAPP) forms amyloid fibrils that accumulate in pancreatic β-cells of Type II Diabetes (T2D) patients. Recently discovered small molecules that modulate the kinetics of hIAPP amyloid formation could serve as starting points for developing T2D therapeutics, but no structural or mechanistic rationale exists to explain their binding mechanisms or effects on hIAPP aggregation pathways....

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Identifiers and source

Literature Corpus work: 4ab56edd-a403-5c24-a54d-91b25c8bcb66
DOI: 10.1101/2025.09.22.677832

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