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Article

Mutational scan inferred binding energetics and structure in intrinsically disordered protein CcdA.

Protein science : a publication of the Protein Society - 1 Mar 2023

Chandra Soumyanetra, Manjunath Kavyashree, Asok Aparna, Varadarajan Raghavan

Abstract excerpt

Unlike globular proteins, mutational effects on the function of Intrinsically Disordered Proteins (IDPs) are not well-studied. Deep Mutational Scanning of a yeast surface displayed mutant library yields insights into sequence-function relationships in the CcdA IDP. The approach enables facile prediction of interface residues and local structural signatures of the bound conformation. In contrast to previous...

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Intrinsically Disordered Proteins
Ligands
Mutation
Protein Binding
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation, alpha-Helical

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PMID: 36714997
DOI: 10.1002/pro.4580
PMCID: PMC9951195

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