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Article

A Mathematical Model for Smooth Muscle Cell Phenotype Switching In Atherosclerotic Plaque.

Bulletin of mathematical biology - 11 Apr 2026

Ndenda Joseph P, Watson Michael G, Misra Ashish, Myerscough Mary R

Abstract excerpt

Smooth muscle cells (SMCs) play a fundamental role in the development of atherosclerotic plaques. They ingest lipids in a similar way to monocyte-derived macrophages (MDMs) in the plaque. This can stimulate SMCs to undergo a phenotypic switch to a macrophage-like phenotype. We formulate an ordinary differential equation (ODE) model for the populations of SMCs, MDMs and smooth muscle cell-derived macrophages...

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Share to Atherosclerosis
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Share to Lipid Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages

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Share to Models, Cardiovascular

Share to Myocytes, Smooth Muscle

Share to Plaque, Atherosclerotic

Source

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Identifiers

PMID: 41963727
DOI: 10.1007/s11538-026-01645-z
PMCID: PMC13068761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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