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Article

Role of vascular smooth muscle cell phenotypic switching in plaque progression: A hybrid modeling study.

Journal of theoretical biology - 7 Oct 2021

Pan Jichao, Cai Yan, Liu Mengchen, Li Zhiyong

Abstract excerpt

Growing genetic lineage mapping experiments have definitively shown a wide-ranging plasticity of vascular smooth muscle cells (VSMCs) in atherosclerotic plaque and suggested that VSMCs can modulate their phenotypes in response to plaque microenvironment. Here, a multiscale hybrid discrete-continuous (HDC) modeling system is established to investigate the complex role of VSMC phenotypic switching within...

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Share to Atherosclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

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Share to Plaque, Atherosclerotic

Source

Identifiers

PMID: 34087268
DOI: 10.1016/j.jtbi.2021.110794

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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