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Profound gene expression changes in the epithelial monolayer of active ulcerative colitis and Crohn’s disease

11 Mar 2022

Abstract excerpt

In recent years it has become apparent that the epithelium is highly involved in inflammatory bowel disease (IBD) pathophysiology. The majority of gene expression studies of IBD are generated from heterogeneous biopsies, providing no distinction between immune cells, the epithelium and other mucosal cells. By using laser capture microdissection (LCM) coupled with RNA sequencing, we aimed to characterize the...

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PMID: 35275975
DOI: 10.1371/journal.pone.0265189

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