Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of Cytochrome b5 Content on the Activity of Polymorphic CYP1A2, 2B6, and 2E1 in Human Liver Microsomes.

PloS one - 1 Jan 2015

Zhang Haifeng, Gao Na, Liu Tingting, Fang Yan, Qi Bing, Wen Qiang, Zhou Jun, Jia Linjing, Qiao Hailing

Abstract excerpt

Human cytochrome b5 (Cyt b5) plays important roles in cytochrome P450 (CYP)-mediated drug metabolism. However, the expression level of Cyt b5 in normal human liver remains largely unknown. The effect of Cyt b5 on overall CYP activity in human liver microsomes (HLM) has rarely been reported and the relationship between Cyt b5 and the activity of polymorphic CYP has not been systematically investigated. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 CYP1A2
Share to Cytochrome P-450 CYP2B6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2E1

Share to Cytochromes b5

Share to Kinetics

Share to Microsomes, Liver

Share to Sex Factors

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 26046844
DOI: 10.1371/journal.pone.0128547
PMCID: PMC4457846

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of Cytochrome b5 Content on the Activity of Polymorphic CYP1A2, 2B6, and 2E1 in Human Liver Microsomes.PMID 26046844Read ↗

Cytochrome b5 Is a Major Determinant of Human Cytochrome P450 CYP2D6 and CYP3A4 Activity In VivoSemantic proximity Read ↗

Impact of POR and cytochrome b5 variability on the genotype-phenotype discordance of CYP2A6 and CYP2D6: A quantitative analysis in Chinese human livers.Semantic proximity Read ↗

Functional characterization of eight human CYP1A2 variants: the role of cytochrome b5.Semantic proximity Read ↗

CYP3A4 and CYP3A5: the crucial roles in clinical drug metabolism and the significant implications of genetic polymorphismsSemantic proximity Read ↗

Physiological Content and Intrinsic Activities of 10 Cytochrome P450 Isoforms in Human Normal Liver Microsomes.Semantic proximity Read ↗

Allele and genotype frequencies of CYP2B6 and CYP3A5 in the Japanese population.Semantic proximity Read ↗

Hepatic CYP2B6 is altered by genetic, physiologic, and environmental factors but plays little role in nicotine metabolism.Semantic proximity Read ↗

Genetic variability in CYP3A5 and its possible consequences.Semantic proximity Read ↗

Gene symbol: CYP1B1.Semantic proximity Read ↗

Gene symbol: CYP1B1.Semantic proximity Read ↗

Gene symbol: CYP1B1.Semantic proximity Read ↗

Gene symbol: CYP1B1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.