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Article

Whole-genome sequencing reveals an East Asian-specific rare variant of INPP5J associated with Alzheimer's disease.

Translational psychiatry - 8 Apr 2026

Kimura Tetsuaki, Yamakawa Akiko, Mitsumori Risa, Niida Shumpei, Ozaki Kouichi, Shigemizu Daichi

Abstract excerpt

Late-onset Alzheimer's disease (LOAD) is the most common form of dementia in the elderly, yet no curative treatments are available. Although genome-wide association studies (GWASs) have identified numerous genetic risk factors, these factors often differ among ethnic groups, and the mechanisms driving LOAD onset remain poorly understood. Most GWASs of LOAD have been conducted in European populations; the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41951582
DOI: 10.1038/s41398-026-04027-0
PMCID: PMC13183990

Genes

INPP5J
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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