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A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.

Psychiatric genetics - 1 Aug 2015

Hirano Atsushi, Ohara Tomoyuki, Takahashi Atsushi, Aoki Masayuki, Fuyuno Yuta, Ashikawa Kyota, Morihara Takashi, Takeda Masatoshi, Kamino Kouzin, Oshima Etsuko, Okahisa Yuko, Shibata Nobuto, Arai Heii, Akatsu Hiroyasu, Ikeda Masashi, Iwata Nakao, Ninomiya Toshiharu, Monji Akira, Kitazono Takanari, Kiyohara Yutaka, Kubo Michiaki, Kanba Shigenobu

Abstract excerpt

OBJECTIVE: Although a number of genome-wide association studies (GWASs) of late-onset Alzheimer's disease (LOAD) have been carried out, there have been little GWAS data on East Asian populations. DESIGN: To discover the novel susceptibility loci of LOAD, we carried out a GWAS using 816 LOAD cases and 7992 controls with a replication analysis using an independent panel of 1011 LOAD cases and 7212 controls in a...

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Identifiers

PMID: 26049409
DOI: 10.1097/YPG.0000000000000090

Genes

APOE
CNTNAP2

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