Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study.

EBioMedicine - 1 Sept 2020

Yuan Shuai, Carter Paul, Bruzelius Maria, Vithayathil Mathew, Kar Siddhartha, Mason Amy M, Lin Ang, Burgess Stephen, Larsson Susanna C

Abstract excerpt

BACKGROUND: Tumour necrosis factor (TNF) inhibitors are used in the treatment of certain autoimmune diseases but given the role of TNF in tumour biology and atherosclerosis, such therapies may influence the risk of cancer and cardiovascular disease. We conducted a Mendelian randomization study to explore whether TNF levels are causally related to cardiovascular disease and cancer. METHODS: Single-nucleotide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular Diseases
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Mendelian Randomization Analysis

Share to Meta-Analysis as Topic

Share to Neoplasms

Share to Odds Ratio

Share to Tumor Necrosis Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 32805626
DOI: 10.1016/j.ebiom.2020.102956
PMCID: PMC7452586

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study.PMID 32805626Read ↗

TNF inhibitors associated with cardiovascular diseases and cardiometabolic risk factors: a Mendelian randomization study.Semantic proximity Read ↗

Mendelian randomization study on the causal effects of tumor necrosis factor inhibition on coronary artery disease and ischemic stroke among the general population.Semantic proximity Read ↗

The Role of Tumor Necrosis Factor Signaling in Atherosclerosis and StrokeSemantic proximity Read ↗

Genetic variants of tumor necrosis factor superfamily, member 4 (TNFSF4), and risk of incident atherothrombosis and venous thromboembolism.Semantic proximity Read ↗

Association of Methylation Signals With Incident Coronary Heart Disease in an Epigenome-Wide Assessment of Circulating Tumor Necrosis Factor αSemantic proximity Read ↗

Genetically Determined Levels of Circulating Cytokines and Risk of StrokeSemantic proximity Read ↗

Exploring the potential impact of TNF-α inhibition on major depressive disorder risk: Insights from a prospective cohort and genetic evidence.Semantic proximity Read ↗

The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation studySemantic proximity Read ↗

Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk.Semantic proximity Read ↗

Association of genetically proxied cancer-targeted drugs with cardiovascular diseases through Mendelian randomization analysis.Semantic proximity Read ↗

The Causal Role of Circulating Inflammatory Cytokines in Brain Tumors: Insights from Genetic Epidemiology.Semantic proximity Read ↗

Causal relationship between matrix metalloproteinase and pulmonary embolism: a bidirectional two-sample Mendelian randomization study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.