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Investigating the Role of TNF-Alpha through Blood-Brain Barrier Integrity in Stress-Induced Depression.

Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology - 1 Dec 2024

Nagy Tamas, Baksa Daniel, Petschner Peter, Gonda Xenia, Gal Zsofia, Juhasz Gabriella, Bagdy Gyorgy

Abstract excerpt

BACKGROUND: Major depressive disorder (MDD) is a complex psychiatric condition significantly impacted by environmental stress and inflammation. Previous research suggests that stress-induced alterations in the blood-brain barrier (BBB) may allow pro-inflammatory cytokines like interleukin-6 (IL-6) to enter the brain, contributing to depression. Tumor necrosis factor-alpha (TNF-α) is another prominent cytokine...

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PMID: 39760673

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