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Article

Metabolic profiling reveals pyrimidine synthesis enzyme CAD as a central carbon metabolism signaling node in cancer cell proliferation.

Molecular cell - 16 Apr 2026

Qin Chao, An Zhenhao, Feng Shu, Fu Wen, Xie Xinchi, Savas Ali Can, Xie Taolin, Brenner Charles, Saito Takeshi, Feng Pinghui

Abstract excerpt

Rapid cancer cell proliferation requires extensive macromolecular biosynthesis, yet how distinct anabolic pathways are coordinated remains incompletely understood. Here, we report that the trifunctional carbamoyl-phosphate synthase, aspartate transcarbamoylase, and dihydroorotase (CAD) activates key glycolytic enzymes to support biosynthesis and cancer cell proliferation. When cancer proteomics datasets were...

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Share to Aspartate Carbamoyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41950920
DOI: 10.1016/j.molcel.2026.03.016
PMCID: PMC13218271

Genes

CAD
G6PD
PHGDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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