Article
BRCA1 and BRCA2 pathogenic variants increase the risk of four less common cancer types.
ESMO open - 1 Apr 2026
Sasagawa H, Endo M, Iwasaki Y, Usui Y, Koyanagi Y N, Innella G, Hadler J, Parsons M T, Numakura K, Kamatani Y, Murakami Y, Matsuo K, Matsuda K, Spurdle A B, Habuchi T, Momozawa Y
Abstract excerpt
BACKGROUND: Previous family-based and case-control studies have expanded the cancer risk profile associated with pathogenic variants in BRCA1 and BRCA2, providing the potential for expanding personalized medicine. Less common cancer types may benefit greatly from such expansion of genetic evidence because of their limited treatments and poor prognoses. METHODS: We conducted a case-control analysis of 3489...
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