Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline mutations in DNA repair genes are associated with bladder cancer risk and unfavourable prognosis.

BJU international - 1 Nov 2018

Na Rong, Wu Yishuo, Jiang Guangliang, Yu Hongjie, Lin Xiaoling, Wang Meilin, Conran Carly A, Fantus Richard J, Zhang Ning, Liu Shenghua, Helfand Brian T, Zheng Siqun L, Isaacs William B, Ding Qiang, Shen Zhoujun, Xu Jianfeng

Abstract excerpt

OBJECTIVES: To perform a systematic evaluation of whether germline DNA repair gene mutations in bladder cancer (BCa) are associated with increased risk of BCa and aggressive disease. MATERIALS AND METHODS: Germline DNA from 98 patients with BCa was analysed for 54 DNA repair genes using a customized targeted sequencing panel. Population control data were obtained from the public databases the Exome Aggregation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to DNA Repair

Share to Genetic Predisposition to Disease

Share to Germ-Line Mutation

Share to Prognosis

Share to Urinary Bladder Neoplasms

Source

Identifiers

PMID: 29727914
DOI: 10.1111/bju.14370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline mutations in DNA repair genes are associated with bladder cancer risk and unfavourable prognosis.PMID 29727914Read ↗

Inherited Germline Cancer Susceptibility Gene Variants in Individuals with Non–Muscle-Invasive Bladder CancerSemantic proximity Read ↗

Genetic alterations and biological pathways in human bladder cancer pathogenesisSemantic proximity Read ↗

Incidence of Germline Variants in Familial Bladder Cancer and Among Patients With Cancer Predisposition Syndromes.Semantic proximity Read ↗

The germline mutational landscape of genitourinary cancers and its indication for prognosis and riskSemantic proximity Read ↗

Targeted Deep Sequencing of Bladder Tumors Reveals Novel Associations between Cancer Gene Mutations and Mutational Signatures with Major Risk Factors.Semantic proximity Read ↗

Epidemiological Trends and Germline Variant Analysis of Young-Onset Bladder Cancer.Semantic proximity Read ↗

Inherited mutations in Chinese patients with upper tract urothelial carcinoma.Semantic proximity Read ↗

Genetic characteristics and targeted treatments of primary bladder and urachal adenocarcinomas: a systematic review with pooled descriptive genomic analyses.Semantic proximity Read ↗

Population Estimates of Ovarian Cancer Risk in a Cohort of Patients with Bladder Cancer.Semantic proximity Read ↗

Inherited Germline Variants in Urinary Tract Cancer: A Multicenter Whole-Exome Sequencing Analysis and Correlation With Clinical Features and Tumor Genomics.Semantic proximity Read ↗

Clinical and genomic profiling of early-onset bladder cancer identifies key alterations and therapeutic targetsSemantic proximity Read ↗

BRCA1 and BRCA2 pathogenic variants increase the risk of four less common cancer types.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.