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Article

Established Cancer Predisposition Genes in Single and Multiple Cancer Diagnoses.

JAMA oncology - 1 Oct 2025

Shevach Jeffrey W, Xu Jianfeng, Snyder Nathan, Wei Jun, Shi Zhuqing, Tran Huy, Zheng S Lilly, Beebe-Dimmer Jennifer L, Cooney Kathleen A

Abstract excerpt

Importance: Much of the understanding of cancer risk associated with rare pathogenic variants (RPVs) is derived from family-based studies or clinically ascertained samples, which may be limited by ascertainment and selection bias. Objective: To quantify associations between RPVs in previously implicated cancer predisposition genes and single and multiple cancer diagnoses in a large population-based study. Design,...

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Source

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Identifiers

PMID: 40875208
DOI: 10.1001/jamaoncol.2025.2879
PMCID: PMC12395360

Genes

ATM
BARD1
BRCA1
BRCA2
BRIP1
CDKN2A
CHEK2
HOXB13
MITF
MLH1
MSH2
MSH6
NF1
PALB2
RAD51C
RAD51D

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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