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Article

Inherited mutations in Chinese patients with upper tract urothelial carcinoma.

Cell reports. Medicine - 17 Jan 2023

Wu Junlong, Jin Shengming, Gu Chengyuan, Wei Yu, Zhu Yao, Necchi Andrea, Shariat Shahrokh F, Pan Jian, Gan Hualei, Dai Bo, Zhang Hailiang, Shi Guohai, Zhu Yu, Shen Yijun, Zhu Yiping, Ye Dingwei

Abstract excerpt

Upper tract urothelial carcinoma (UTUC) accounts for 10% of urothelial carcinomas (UCs) and has a substantial hereditary component. However, the majority of our knowledge of germline spectrum comes from bladder cancer (BCa) data in White populations. Here, we sequence 309 Chinese UTUC cases and identify 71 germline pathogenic/likely pathogenic (P/LP) mutations in 62 patients (20.1%). Compared with White cases, we...

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Share to Bladder and Urothelial Cancer Treatments
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36630951
DOI: 10.1016/j.xcrm.2022.100883
PMCID: PMC9873949

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