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Article

Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants.

JAMA oncology - 1 Jun 2022

Momozawa Yukihide, Sasai Rumi, Usui Yoshiaki, Shiraishi Kouya, Iwasaki Yusuke, Taniyama Yukari, Parsons Michael T, Mizukami Keijiro, Sekine Yuya, Hirata Makoto, Kamatani Yoichiro, Endo Mikiko, Inai Chihiro, Takata Sadaaki, Ito Hidemi, Kohno Takashi, Matsuda Koichi, Nakamura Seigo, Sugano Kokichi, Yoshida Teruhiko, Nakagawa Hidewaki, Matsuo Keitaro, Murakami Yoshinori, Spurdle Amanda B, Kubo Michiaki

Abstract excerpt

Importance: The clinical importance of genetic testing of BRCA1 and BRCA2 in breast, ovarian, prostate, and pancreatic cancers is widely recognized. However, there is insufficient evidence to include other cancer types that are potentially associated with BRCA1 and BRCA2 in clinical management guidelines. Objective: To evaluate the association of BRCA1 and BRCA2 pathogenic variants with additional cancer types...

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Identifiers

PMID: 35420638
DOI: 10.1001/jamaoncol.2022.0476
PMCID: PMC9011177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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