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Article

Prevalence of BRCA1/BRCA2 pathogenic variation in Chinese Han population.

Journal of medical genetics - 1 Aug 2021

Dong Hui, Chandratre Khyati, Qin Yue, Zhang Jing, Tian Xiaoqing, Rong Ce, Wang Ning, Guo Maoni, Zhao Guoping, Wang San Ming

Abstract excerpt

BACKGROUND: Pathogenic variation in BRCA1 and BRCA2 (BRCA) is one of the most frequent genetic predispositions for hereditary breast cancer. The identification of the variant carriers plays an important role in prevention and treatment of cancer. Despite a population size of 1.4 billion and a quarter million annual new breast cancer cases, knowledge regarding the prevalence of BRCA variation in the Chinese...

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PMID: 32467295
DOI: 10.1136/jmedgenet-2020-106970

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