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Article

SV2 renders primed synaptic vesicles competent for Ca2+ -induced exocytosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Jan 2009

Chang Wen-Pin, Südhof Thomas C

Abstract excerpt

Synaptic vesicle protein 2 (SV2), one of the first synaptic vesicle proteins identified, is characterized by multiple transmembrane regions that exhibit homology to sugar transporters, and by a highly glycosylated intravesicular sequence. Deletion of SV2 causes postnatal lethality in mice, primarily because of fulminant epilepsy. At the cellular level, deletion of SV2 impairs neurotransmitter release, but its...

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Identifiers

PMID: 19176798
DOI: 10.1523/JNEUROSCI.4521-08.2009
PMCID: PMC2693337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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