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Article

Synaptic vesicle protein 2 enhances release probability at quiescent synapses.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Jan 2006

Custer Kenneth L, Austin Naola S, Sullivan Jane M, Bajjalieh Sandra M

Abstract excerpt

We report a thorough analysis of neurotransmission in cultured hippocampal neurons lacking synaptic vesicle protein 2 (SV2), a membrane glycoprotein present in all vesicles that undergo regulated secretion. We found that SV2 selectively enhances low-frequency neurotransmission by priming morphologically docked vesicles. Loss of SV2 reduced initial release probability during a train of action potentials but had no...

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Identifiers

PMID: 16436618
DOI: 10.1523/JNEUROSCI.2699-05.2006
PMCID: PMC6674579

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