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Article

Identification and credentialing of patient-derived xenograft models of invasive lobular carcinoma.

Disease models & mechanisms - 1 Apr 2026

Hooda Jagmohan, Atkinson Jennifer M, Shah Osama Shiraz, Yates Megan, Brown Daniel D, DeBerry Morgan, Cairo Stefano, Schiavini Paolo, Tsai Hsiu-Wen, Zipeto Marianna, Bhargava Rohit, Oesterreich Steffi, Lee Adrian V

Abstract excerpt

Invasive lobular cancer (ILC) is the most common special breast cancer subtype, accounting for 10-15% of all cases. The pathognomonic feature of ILC is loss of E-cadherin (encoded by CDH1), leading to discohesive single-file growth. Although ILCs show better prognostic factors than 'no special type' (NST) breast cancer, patients with ILC have worse long-term outcomes. We identified and validated patient-derived...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41943626
DOI: 10.1242/dmm.052710
PMCID: PMC13225211

Genes

CDH1
PIK3CA
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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