Genomic Characterization of Primary Invasive Lobular Breast Cancer.

doi:10.1200/JCO.2015.64.0334

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Article

Genomic Characterization of Primary Invasive Lobular Breast Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jun 2016

Desmedt Christine, Zoppoli Gabriele, Gundem Gunes, Pruneri Giancarlo, Larsimont Denis, Fornili Marco, Fumagalli Debora, Brown David, Rothé Françoise, Vincent Delphine, Kheddoumi Naima, Rouas Ghizlane, Majjaj Samira, Brohée Sylvain, Van Loo Peter, Maisonneuve Patrick, Salgado Roberto, Van Brussel Thomas, Lambrechts Diether, Bose Ron, Metzger Otto, Galant Christine, Bertucci François, Piccart-Gebhart Martine, Viale Giuseppe, Biganzoli Elia, Campbell Peter J, Sotiriou Christos

Abstract excerpt

PURPOSE: Invasive lobular breast cancer (ILBC) is the second most common histologic subtype after invasive ductal breast cancer (IDBC). Despite clinical and pathologic differences, ILBC is still treated as IDBC. We aimed to identify genomic alterations in ILBC with potential clinical implications. METHODS: From an initial 630 ILBC primary tumors, we interrogated oncogenic substitutions and insertions and...

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Identifiers

PMID: 26926684
DOI: 10.1200/JCO.2015.64.0334

Genes

AKT1
ESR1
FOXA1
CDH1
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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