Evaluation of quantitative muscle MRI and an intelligent phenotyping housing system as advanced phenotyping methods in a mouse model of calpain 3-deficient muscular dystrophy.

Abstract excerpt

Calpainopathy is a rare genetic myopathy without causal treatment available. Recent advances have produced promising treatment strategies, including genetic treatment and immunomodulation, that are currently being tested pre-clinically in murine models. Traditional behavioral assays frequently fail to detect early motor deficits in corresponding mouse models. Thus, this study investigated whether more...

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