Article
Non-invasive MRI and spectroscopy of mdx mice reveal temporal changes in dystrophic muscle imaging and in energy deficits.
PloS one - 1 Jan 2014
Heier Christopher R, Guerron Alfredo D, Korotcov Alexandru, Lin Stephen, Gordish-Dressman Heather, Fricke Stanley, Sze Raymond W, Hoffman Eric P, Wang Paul, Nagaraju Kanneboyina
Abstract excerpt
In Duchenne muscular dystrophy (DMD), a genetic disruption of dystrophin protein expression results in repeated muscle injury and chronic inflammation. Magnetic resonance imaging shows promise as a surrogate outcome measure in both DMD and rehabilitation medicine that is capable of predicting clinical benefit years in advance of functional outcome measures. The mdx mouse reproduces the dystrophin deficiency that...
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