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Article

Longitudinal MEMRI analysis of brain phenotypes in a mouse model of Niemann-Pick Type C disease.

NeuroImage - 15 Aug 2020

Rallapalli Harikrishna, Darwin Benjamin C, Toro-Montoya Estefania, Lerch Jason P, Turnbull Daniel H

Abstract excerpt

Niemann-Pick Type C (NPC) is a rare genetic disorder characterized by progressive cell death in various tissues, particularly in the cerebellar Purkinje cells, with no known cure. Mouse models for human NPC have been generated and characterized histologically, behaviorally, and using longitudinal magnetic resonance imaging (MRI). Previous imaging studies revealed significant brain volume differences between...

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Algorithms
Cerebellar Cortex
Contrast Media
Magnetic Resonance Imaging
Manganese

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Niemann-Pick Disease, Type C

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PMID: 32417449
DOI: 10.1016/j.neuroimage.2020.116894
PMCID: PMC7443857

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