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Article

Distribution of MRI-derived T2 values as a biomarker for in vivo rapid screening of phenotype severity in mdx mice.

PloS one - 1 Jan 2024

Waters Emily A, Haney Chad R, Vaught Lauren A, McNally Elizabeth M, Demonbreun Alexis R

Abstract excerpt

BACKGROUND: The pathology in Duchenne muscular dystrophy (DMD) is characterized by degenerating muscle fibers, inflammation, fibro-fatty infiltrate, and edema, and these pathological processes replace normal healthy muscle tissue. The mdx mouse model is one of the most commonly used preclinical models to study DMD. Mounting evidence has emerged illustrating that muscle disease progression varies considerably in...

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Identifiers

PMID: 39298449
DOI: 10.1371/journal.pone.0310551
PMCID: PMC11412503

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