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Article

Subtype-Specific Causal Effects of C16 and C24 Ceramides on Heart Failure: Evidence From Univariable and Multivariable Mendelian Randomization Analyses.

Lipids - 1 Sept 2026

Wang Zeda, Xue Yakui, Han Kaishan

Abstract excerpt

Ceramides (Cer) are bioactive lipids implicated in cardiovascular disease (CVD), yet their subtype-specific causal effects remain unclear. We performed a two-sample Mendelian randomization (MR) analysis using publicly available GWAS summary statistics to investigate the effects of C16:0-ceramide homologs (Cer16:0) and C24:1-ceramide homologs (Cer24:1) on six CVD outcomes. Instrumental variables were rigorously...

Read the complete abstract on PubMed

Topics

Ceramides
Mendelian Randomization Analysis
Heart Failure
Humans
Genome-Wide Association Study
Polymorphism, Single Nucleotide

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Identifiers

PMID: 41943390
DOI: 10.1002/lipd.70054
PMCID: PMC13568880

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