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Article

Plasma lipidome mediates the causal effect of chronic hepatitis B on cirrhosis: A Mendelian randomization study.

Medicine - 10 Apr 2026

Xiao Biao, Song Qixiang, Wang Zhenggang, Huang Jie, Liu Ying, Li Boqi, Zeng Qinghai, Deng Yelin, Krol Ewelina, Khouri Ricardo, De Clercq Erik, Zhang Min, Li Guangdi

Abstract excerpt

This study aimed to investigate the role of the plasma lipid species in the progression from chronic hepatitis B (CHB) infection to cirrhosis. We conducted 2-sample Mendelian randomization (MR) and genome-wide mediation analyses to explore the causal relationship between CHB and cirrhosis, focusing on lipid species as potential mediators. The inverse variance weighted method was used as the primary analytical...

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PMID: 41961698
DOI: 10.1097/MD.0000000000048252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 11 Sept 2026.

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