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Article

Unraveling the Lipidomic Determinants of Atrial Fibrillation: An Extensive Mendelian Randomization Study

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2026

Ye Lingyan, Lin Dongli, Chen Feng, Huang Xiaoyong, Wu Xianjun

Abstract excerpt

BACKGROUND: Atrial Fibrillation (AF) is the most prevalent form of cardiac arrhythmia, with a complex etiology that implicates lipid metabolism. This study employs Mendelian Randomization (MR) to dissect the causal relationships between lipidomic profiles and AF, utilizing comprehensive genetic data to clarify these associations. METHODS: Summary statistics for 179 lipid species across 13 classes were retrieved...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40304325
DOI: 10.2174/0118715303378914250418095928
PMCID: PMC13334236

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