Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extensive genetic interactions (epistasis) linked to alcohol use disorder in a high-risk population.

Communications biology - 6 Apr 2026

Listopad Stanislav, Peng Qian

Abstract excerpt

Alcohol use disorder (AUD) is known to have a significant genetic component, yet there remains a gap between its heritability and findings from genome-wide association studies. One potential explanation for this could be genetic interactions, or epistasis, which remain largely unexplored in the context of AUD. We investigated the role of epistasis in AUD susceptibility among 742 American Indians. By analyzing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholism
Share to Epistasis, Genetic
Share to CNTNAP2 gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CSMD1 gene

Share to ERBB4 gene

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 41942605
DOI: 10.1038/s42003-026-09971-7
PMCID: PMC13230857

Genes

CSMD1
CNTNAP2
DLGAP1
ERBB4
GRM8
KCNQ5
MAML2
ROBO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extensive genetic interactions (epistasis) linked to alcohol use disorder in a high-risk population.PMID 41942605Read ↗

EXTENSIVE GENETIC INTERACTIONS (EPISTASIS) LINKED TO ALCOHOL USE DISORDER IN A HIGH-RISK POPULATIONSemantic proximity Read ↗

Identification of Novel Loci and Cross-Disorder Pleiotropy Through Multi-Ancestry Genome-Wide Analysis of Alcohol Use Disorder in Over One Million IndividualsSemantic proximity Read ↗

Diverse types of genomic evidence converge on alcohol use disorder risk genes.Semantic proximity Read ↗

Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases.Semantic proximity Read ↗

Shared Genetic Architecture and Neurobiological Pathways of Problematic Alcohol Use and Anxiety DisordersSemantic proximity Read ↗

Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence.Semantic proximity Read ↗

Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.Semantic proximity Read ↗

A New Genomewide Association Meta-Analysis of Alcohol Dependence.Semantic proximity Read ↗

Genetics of GABAergic signaling in nicotine and alcohol dependence.Semantic proximity Read ↗

Genetics of alcoholism.Semantic proximity Read ↗

Integrative Analysis of Genetic, Genomic, and Phenotypic Data for Ethanol Behaviors: A Network-Based Pipeline for Identifying Mechanisms and Potential Drug Targets.Semantic proximity Read ↗

The Collaborative Study on the Genetics of Alcoholism: Overview.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.