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Article

Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence.

American journal of human genetics - 5 Dec 2013

Han Shizhong, Yang Bao-Zhu, Kranzler Henry R, Liu Xiaoming, Zhao Hongyu, Farrer Lindsay A, Boerwinkle Eric, Potash James B, Gelernter Joel

Abstract excerpt

Despite a significant genetic contribution to alcohol dependence (AD), few AD-risk genes have been identified to date. In the current study, we aimed to integrate genome-wide association studies (GWASs) and human protein interaction networks to investigate whether a subnetwork of genes whose protein products interact with one another might collectively contribute to AD. By using two discovery GWAS data sets of...

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Identifiers

PMID: 24268660
DOI: 10.1016/j.ajhg.2013.10.021
PMCID: PMC3853414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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