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Article

Osteoarthritis and analgesic consumption in haemochromatosis HFE C282Y homozygotes with normal or low iron parameters.

Nature communications - 7 Apr 2026

Helby Jens, Mottelson Mathis, Bojesen Stig Egil, Nordestgaard Børge Grønne, Faurschou Mikkel, Petersen Jesper, Ellervik Christina, Warny Marie, Glenthøj Andreas

Abstract excerpt

We studied 132,525 Danish general population individuals to examine whether risk of osteoarthritis and/or use of pain-relieving medication was increased in haemochromatosis C282Y homozygotes with normal or low plasma iron, transferrin saturation, or ferritin. We genotyped all 132,525 individuals for the HFE C282Y and H63D variants. During a median follow-up of 40 years, 31,636 individuals had osteoarthritis. Risk...

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Denmark
Ferritins
Hemochromatosis
Hemochromatosis Protein
Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41942437
DOI: 10.1038/s41467-026-71367-2
PMCID: PMC13234027

Genes

HFE

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Osteoarthritis and analgesic consumption in haemochromatosis HFE C282Y homozygotes with normal or low iron parameters.PMID 41942437Read ↗

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